Takes place in 2019, narrated the lives of vampires has been revolutionized over the face of the Earth. They are now dominated by the clan that humans have encountered a point where they will become extinct. Of course, human extinction will threaten the position of the vampires in the future. For this reason a medical company Bromley Marks established, which is to find the right formula to replace human blood as the main food of the vampire. Meanwhile, in the outside world, there peculiarities in the vampire that has long not because of scarcity of drinking human blood. Gene their bodies change and mutate to produce a creature with appearance and behavior that is more terrible. Is Edward Dalton (Ethan Hawke), a vampire who is a principal investigator in the enterprise, which is tasked to lead the search team of the blood substitute formula. Under the leadership of Charles Bromley (Sam Neill), the vampire owner of the company, Edward actually has another purpose in finding the formula: He can not stand the fact that man is only used as an ingredient hunted for blood drawn, so that Edward wants with this formula, humans will be saved population.